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The approach must be rigorously medical: careful patient selection, protocol personalisation and monitoring with objective parameters, within the context of an integrated anti-ageing plan that includes lifestyle, nutrition and targeted therapies. References Radenkovic D, Verdin E

Pharmacol Ther 113:154164 Hwang AB, Lee SJ (2011) Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection

464 Amplification of IFN / genes during the late phase enhances the pro-inflammatory response, increasing the infiltration of type I IFN-producing effector cells, further amplifying the inflammatory response

O-glcnacylation enhances the translocation of NF-B by inhibiting the interaction of NF-B with IB

& MITHEN, R